As scientists look ahead, they hope to learn more about the genetic modifications needed in transplanted animal organs and continue clinical trials. “We have gained invaluable insights learning that the genetically modified pig heart can function well within the human body while the immune system is adequately suppressed,” said Muhammad Mohiuddin, one of the surgeons who performed the procedure. The heart functioned well without rejection for about two months, but his condition began deteriorating and he passed away on March 8. The organ had 10 genetic modifications to ensure Bennett’s body did not reject the organ, and the modifications also ensured that a heart from a 400 kg animal remained human-sized. In January 2022, surgeons at the University of Maryland Medical Center transplanted a heart from a genetically modified pig into 57-year-old David Bennett. health care system must rethink which hospitals should do heart transplants.Ĭiting studies from Cardiology Research and other scientific publications, Healthmatch compiled a timeline of the development of an alternative human heart.īSIP/Universal Images Group via Getty Images “The bar for patient safety, quality of care, and survival needs to be set pretty high,” said senior study investigator and cardiac surgeon John Conte. Patients who receive their transplants at high-volume facilities have a better survival rate and fewer complications.
In 2008, surgeons at Johns Hopkins Medicine recommended that for a hospital to be named a high-volume facility, it should perform 14 procedures a year-an increase from the earlier benchmark of 10 procedures a year. When retired dentist Barney Clark received a total artificial heart in December 1982, it made medical history because there was no realistic prospect that it would ever be replaced with a biological transplant. Their goal is to provide artificial hearts as a temporary option so that patients who would not otherwise survive on a temporary pump have more time until a donor heart can be found. The challenge of finding a donor heart has long motivated scientists to develop an artificial heart. A 2021 study published in the Journal of the American Heart Association found that over the past decade, the percentage of organs accepted for transplant has not increased proportionally to the number of donor hearts offered for transplant. About 2,000 hearts are available each year for transplantation, but more than 3,000 people are on the heart transplant list.
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